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| Nicolas Cage | Sailor | |
| Laura Dern | Lula | |
| Willem Dafoe | Bobby Peru | |
| J.E. Freeman | Santos | |
| Crispin Glover | Dell | |
| Diane Ladd | Marietta Fortune | |
| Calvin Lockhart | Reggie | |
| Isabella Rossellini | Perdita | |
| Harry Dean Stanton | Johnnie Farragut | |
| Grace Zabriskie | Juana | |
| Sherilyn Fenn | Girl in Accident | |
| Marvin Kaplan | Uncle Pooch | |
| William Morgan Sheppard | Mr. Reindeer | |
| David Patrick Kelly | Dropshadow | |
| Freddie Jones | George Kovich | |
| John Lurie | Sparky | |
| Jack Nance | 00 Spool | |
| Pruitt Taylor Vince | Buddy | |
| Gregg Dandridge | Bob Ray Lemon | |
| Glenn Walker Harris Jr. | Pace |
| Director |
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| Producer |
Steve Golin
Michael Kuhn Monty Montgomery Sigurjon Sighvatsson |
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| Writer |
Barry Gifford
David Lynch |
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| Cinematography |
Frederick Elmes
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| Musician |
Angelo Badalamenti
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Young lovers Sailor and Lula hit the road to start a new life together away from the wrath of Lula’s deranged, disapproving mother, who has hired a team of hitmen to cut the lovers’ surreal honeymoon short. |
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